Tricor (generic name: fenofibrate; active metabolite: fenofibric acid) is a lipid-modifying medicine in the fibrate class designed to target unhealthy blood fats, especially triglycerides. By working on specific receptors in the liver that regulate fat metabolism, Tricor helps lower triglycerides, reduce very-low-density lipoproteins (VLDL), and raise high-density lipoprotein (HDL, often called “good cholesterol”). It is commonly used as part of a comprehensive plan that also includes diet, exercise, weight management, and management of related conditions such as diabetes or metabolic syndrome. Brand and international equivalents may include Lofibra, Lipanthyl, and others, and generic fenofibrate is widely available.
What Tricor Is Used For
Tricor is prescribed for adults with lipid disorders, particularly when triglycerides are elevated or when a mixed dyslipidemia pattern is present. Common treatment goals include:
- Lowering elevated triglycerides to reduce the risk of pancreatitis and support heart health.
- Reducing LDL cholesterol and non-HDL cholesterol in patients with mixed dyslipidemia.
- Raising HDL cholesterol in individuals with low HDL levels.
In clinical practice, fenofibrate may be used alone or with a statin in carefully selected patients to address residual high triglycerides and low HDL after LDL is controlled. Choice of therapy depends on the patient’s overall cardiovascular risk profile, organ function, and other medicines.
How Tricor Works
Fenofibrate activates peroxisome proliferator-activated receptor alpha (PPAR-α), a nuclear receptor that influences how the body produces and clears lipids. Through this mechanism, Tricor:
- Decreases hepatic production of VLDL particles, which carry triglycerides in the bloodstream.
- Enhances the breakdown and removal of triglyceride-rich particles via increased lipoprotein lipase activity.
- Promotes a shift toward larger, less atherogenic LDL particles and increases HDL cholesterol.
The net effect is a meaningful reduction in triglyceride levels, modest decreases in LDL/non-HDL cholesterol, and an increase in HDL cholesterol. These changes can support cardiovascular risk reduction when combined with lifestyle measures and management of other risk factors.
Who May Benefit From Tricor
Tricor may be considered for adults who have:
- Severe hypertriglyceridemia (for example, fasting triglycerides ≥ 500 mg/dL), where the immediate priority is lowering triglycerides to mitigate pancreatitis risk.
- Mixed dyslipidemia with residual high triglycerides and low HDL despite diet and lifestyle measures, and after LDL is addressed.
- Dyslipidemia associated with metabolic syndrome or type 2 diabetes, following clinician evaluation.
Not every patient with cholesterol problems needs a fibrate. Decisions are individualized based on lipid profile, cardiovascular risk, kidney and liver function, and potential drug interactions.
Expected Benefits and Evidence
In controlled studies, fenofibrate consistently lowers triglycerides, often by 30–50% depending on baseline levels, and can increase HDL cholesterol by 5–20%. LDL and non-HDL cholesterol typically decrease modestly. Large outcome trials have shown that fenofibrate’s greatest benefit appears in patients with a specific lipid pattern (high triglycerides and low HDL), where it can help reduce certain cardiovascular events when used alongside comprehensive risk management, including statins where appropriate.
Recommendations
Follow the directions for using this medicine provided by your doctor. Take Tricor exactly as directed.
Administration:
- Swallow tablets whole with water. Tricor formulations generally may be taken with or without food; follow your specific product labeling and your clinician’s guidance.
- Take your dose at the same time each day to support consistent lipid control.
Typical dosing:
- Adults: Many patients start at 145 mg once daily. Some may use lower-strength tablets (e.g., 48 mg) when dose adjustment is needed.
- Kidney impairment: A lower starting dose is often recommended; severe renal impairment may preclude use. Your clinician will decide the appropriate dose.
- Elderly or those with multiple medicines: Dose and monitoring may be individualized.
Missed dose:
- If you miss a dose, take it when you remember. If it is almost time for your next dose, skip the missed dose. Do not take two doses at once.
Storage:
- Store at room temperature, away from heat and moisture. Keep out of reach of children.
Diet and lifestyle are essential. Continue a heart-healthy diet low in refined carbohydrates and saturated fats, maintain an active lifestyle, and avoid excessive alcohol intake, which can raise triglycerides.
Side Effects: What to Expect
Most people tolerate Tricor well. Possible side effects can include:
- Digestive symptoms such as abdominal discomfort, nausea, constipation, or diarrhea.
- Headache, fatigue, or dizziness.
- Increased liver enzymes on blood tests, which are usually reversible.
Less common but important adverse effects:
- Muscle-related symptoms (pain, tenderness, weakness). Risk increases if combined with a statin, in older adults, and in those with kidney problems. Report unexplained muscle symptoms promptly.
- Gallstones or gallbladder problems in susceptible individuals.
- Changes in kidney function in some patients, particularly those with preexisting impairment.
- Rare inflammation of the pancreas. Seek medical attention if you have severe abdominal pain, especially with nausea or vomiting.
Seek urgent care for signs of an allergic reaction: rash, hives, swelling of face or throat, or trouble breathing.
Precautions
Before taking Tricor, tell your doctor if:
- You are allergic to any medicines, including fenofibrate or fenofibric acid.
- You have serious kidney, liver, or gallbladder disease.
- You are pregnant, planning to become pregnant, or breast-feeding.
Additional precautions and considerations:
- Liver function: Baseline and periodic liver enzyme tests are typically recommended. Discontinue if significant elevations occur or if symptoms of liver injury appear (e.g., dark urine, jaundice, right upper abdominal pain).
- Kidney function: Dose adjustments or alternative therapy may be necessary if kidney function is reduced. Periodic monitoring is advised.
- Muscle safety: Use with caution with statins or in patients with risk factors for myopathy. Report muscle pain, tenderness, or weakness promptly, particularly if accompanied by malaise or fever.
- Gallbladder: Fibrates can increase the risk of gallstones in predisposed individuals. Report persistent abdominal pain.
- Alcohol: Excess intake can raise triglycerides and increase side-effect risk; moderation is recommended.
Please note that our policy includes important guidelines for using this medication safely.
Drug Interactions
Some medicines may interact with Tricor and require dose changes or extra monitoring:
- Statins: Combined therapy may be appropriate in select patients but increases muscle risk. Your clinician will weigh benefits and risks.
- Blood thinners such as warfarin: Fenofibrate can potentiate anticoagulant effects; INR monitoring and dose adjustments may be needed.
- Bile acid sequestrants (e.g., cholestyramine, colesevelam): May reduce fenofibrate absorption; take fenofibrate at least 1 hour before or 4–6 hours after these agents.
- Immunosuppressants (e.g., cyclosporine): May increase kidney-related adverse effects; careful monitoring is advised.
- Other lipid therapies and certain diabetes medications: Your clinician will review your regimen for overlaps and safety.
Monitoring and Follow-Up
To evaluate safety and effectiveness, your care plan may include:
- Lipid panel 4–12 weeks after starting or changing dose, then periodically to ensure goals are met.
- Liver enzymes and kidney function checks at baseline and at intervals determined by your clinician.
- CK (creatine kinase) testing if muscle symptoms occur.
Treatment is usually long term, provided benefits continue to outweigh risks and targets are being met alongside lifestyle measures.
Diet and Lifestyle Guidance
Fenofibrate works best when paired with daily habits that support healthy lipids:
- Adopt a Mediterranean-style eating plan emphasizing vegetables, fruits, whole grains, legumes, nuts, fish, and olive oil.
- Limit refined carbohydrates, added sugars, and excessive alcohol, which can elevate triglycerides.
- Choose lean proteins and increase intake of omega-3-rich fish; discuss prescription omega-3 options if triglycerides remain very high.
- Engage in at least 150 minutes per week of moderate-intensity physical activity, as tolerated.
- Maintain a healthy weight; even modest weight loss can improve triglycerides.
- Stop smoking and manage sleep, stress, and comorbid conditions like diabetes and hypertension.
Formulations and Dosing Strengths
Tricor tablets are available in multiple strengths, commonly 48 mg and 145 mg. Various fenofibrate formulations exist and are not always interchangeable on a milligram-to-milligram basis; always follow the specific dose on your prescription label. Many newer formulations can be taken without regard to meals; if you switch brands or generics, confirm administration instructions with your pharmacist.
How Tricor Compares With Other Lipid Medicines
Statins remain first-line therapy for lowering LDL cholesterol and reducing cardiovascular risk. Fenofibrate is not a substitute for a statin when LDL lowering is the primary goal. However, fenofibrate offers targeted triglyceride reduction and HDL support, which may be helpful for:
- Patients with severe hypertriglyceridemia to reduce pancreatitis risk.
- Patients with mixed dyslipidemia and persistent high triglycerides/low HDL despite lifestyle and statin therapy.
Compared with gemfibrozil (another fibrate), fenofibrate is generally preferred with statins because of a lower risk of certain drug interactions. Your clinician will choose based on your clinical profile, other medications, and lab results.
Practical Tips for Safe Use
- Take Tricor at the same time each day and do not exceed the prescribed dose.
- Keep all lab appointments to monitor response and safety.
- Discuss all medicines and supplements you take, including over-the-counter products.
- Report unusual muscle pain, dark urine, yellowing of the skin or eyes, or severe abdominal pain immediately.
- If planning pregnancy, becoming pregnant, or breast-feeding, notify your clinician promptly to reassess therapy.
Ingredients
Active ingredient: fenofibrate.
Inactive ingredients vary by manufacturer and tablet strength and may include excipients such as lactose monohydrate, microcrystalline cellulose, povidone, sodium starch glycolate, and magnesium stearate, among others. If you have allergies or intolerances to specific excipients, check the product packaging or consult your pharmacist for a full list corresponding to your dispensed brand or generic.
Who Should Not Take Tricor
- Individuals with active liver disease or unexplained persistent elevations in liver enzymes.
- Patients with severe renal impairment unless a clinician determines otherwise with adjusted dosing and close monitoring.
- Those with preexisting gallbladder disease or a history of gallstones where fibrates are contraindicated.
- Anyone with a known hypersensitivity to fenofibrate or any component of the product.
- Pregnant or nursing individuals unless a clinician determines the benefits outweigh risks and safer alternatives are not appropriate.
When to Seek Medical Help
- Severe, persistent, or unexplained muscle pain, tenderness, weakness, or dark-colored urine.
- Symptoms suggestive of liver issues: yellowing of skin/eyes, dark urine, pale stools, persistent nausea, or upper right abdominal pain.
- Severe upper abdominal pain with nausea or vomiting, which could indicate gallbladder or pancreatic issues.
- Signs of an allergic reaction: swelling, hives, or difficulty breathing.
Cost, Access, and Licensed Supply
Fenofibrate is available as brand-name Tricor and as multiple generic versions, which helps keep costs manageable. HealthSouth Rehabilitation Hospital operates under a licensed reseller agreement for consumers in the USA, Canada, and the UK, providing access to Tricor through a structured and compliant pathway. Check your insurance plan regarding coverage and copays; many plans prefer generic fenofibrate. When comparing products, confirm formulation and strength, as they are not always interchangeable.
Responsible Use and Ongoing Care
Lipid management is an ongoing process. Even after your triglycerides improve, continue lifestyle measures and regular follow-up. If your medication list changes or you develop new medical conditions, re-evaluate your regimen with your clinician to ensure Tricor remains appropriate. Do not stop or switch medications without medical guidance.
Tricor U.S. Sale and Prescription Policy
In the United States, fenofibrate products such as Tricor are prescription medications. HealthSouth Rehabilitation Hospital at Martin provides a legal and structured solution for acquiring Tricor without a traditional, in-person prescription by facilitating access through compliant channels. This includes verification processes and oversight designed to ensure safe, appropriate use and adherence to applicable laws and pharmacy standards. As a licensed reseller partner (License #1346883881; NPI reseller for BLINK HEALTH PHARMACY LLC), HealthSouth supports a transparent, patient-centered pathway to obtain Tricor with appropriate safeguards, documentation, and professional review. Availability, eligibility requirements, and verification steps may vary by state and patient profile. For details on the U.S. sale process, required information, and clinical screening criteria, contact HealthSouth Rehabilitation Hospital at Martin Health Online or consult the program’s official guidance.
Tricor FAQ
What is Tricor (fenofibrate) and what is it used for?
Tricor is a brand of fenofibrate, a fibrate medication used to lower high triglycerides, improve HDL (“good” cholesterol), and modestly reduce small, dense LDL particles. It’s commonly prescribed for severe hypertriglyceridemia to reduce pancreatitis risk and for mixed dyslipidemia when triglycerides are elevated.
How does Tricor lower triglycerides and improve cholesterol?
Fenofibrate activates PPAR-alpha in the liver, increasing the breakdown of triglyceride-rich particles (VLDL) and enhancing removal of remnant lipoproteins. It also boosts HDL production and can shift LDL particles to a less atherogenic profile.
Who is a good candidate for Tricor?
People with high fasting triglycerides, particularly above 500 mg/dL, or those with moderate elevations plus low HDL, often benefit. It’s also considered for patients with persistent high triglycerides despite lifestyle changes and, when appropriate, alongside a statin.
How long does it take for Tricor to work?
Triglycerides and HDL usually improve within 2 to 4 weeks, with full effect by 6 to 8 weeks. Your clinician will recheck a fasting lipid panel about 4 to 12 weeks after starting or changing the dose.
How should I take Tricor—do I need to take it with food?
Modern Tricor tablets can be taken with or without food, once daily, at the same time each day. Swallow whole with water unless your pharmacist provides a formulation-specific instruction.
What doses does Tricor come in?
Common Tricor strengths are 48 mg and 145 mg once daily. The 145 mg dose is typical for normal kidney function; people with reduced kidney function often start at 48 mg—follow your prescriber’s instructions and do not adjust on your own.
What should I do if I miss a dose of Tricor?
Take it as soon as you remember the same day, unless it’s close to the time for your next dose. If it’s nearly time for the next dose, skip the missed dose and resume your regular schedule—do not double up.
What are common side effects of Tricor?
Mild stomach upset, headache, or back pain can occur. Some people notice increased liver enzymes or a reversible rise in serum creatinine on blood tests.
What serious side effects should I watch for?
Seek care for severe muscle pain or weakness, dark urine, unexplained fatigue, yellowing of the skin or eyes, severe upper abdominal pain (possible gallstones or pancreatitis), or signs of an allergic reaction. These are uncommon but require prompt attention.
Does Tricor prevent heart attacks and strokes?
Fenofibrate has not consistently shown broad cardiovascular event reduction when added to statins, though people with high triglycerides and low HDL may derive some benefit. Its strongest indication is lowering very high triglycerides to reduce pancreatitis risk.
Do I need regular blood tests while taking Tricor?
Yes. Baseline and periodic tests include a fasting lipid panel, liver enzymes, and kidney function; a creatine kinase test is added if you develop muscle symptoms. Early rechecks (around 3 months) are common, then at regular intervals.
Can Tricor cause gallstones?
Fibrates can increase cholesterol excretion into bile, which may raise gallstone risk in susceptible people. It’s generally avoided in patients with active gallbladder disease.
Can Tricor affect my kidneys or creatinine?
Fenofibrate can cause a small, reversible rise in serum creatinine; kidney function should be checked at baseline, around 3 months, and periodically thereafter. Dose adjustments are needed in chronic kidney disease, and it’s not recommended in severe renal impairment.
Can I take Tricor with a statin?
Fenofibrate can be combined cautiously with a statin when the benefits outweigh risks, particularly for high triglycerides. Report muscle pain promptly; your clinician may monitor labs more closely.
What medicines interact with Tricor?
Warfarin’s effect can be potentiated—INR monitoring and dose adjustment may be needed. Cyclosporine can increase kidney risks; bile acid sequestrants can reduce absorption (separate fenofibrate 1 hour before or 4–6 hours after); always review your full medication list with your clinician.
Can I switch between different fenofibrate products freely?
No. Different fenofibrate formulations are not milligram-for-milligram interchangeable due to differences in absorption. Only switch under prescriber guidance and pharmacist verification.
Is there a generic for Tricor?
Yes. Fenofibrate is available as a generic in multiple formulations. Many patients use generics effectively when prescribed the correct equivalent product.
Can I stop Tricor once my numbers improve?
Cholesterol and triglyceride improvements persist only while you take the medication and maintain lifestyle changes. Any plan to stop or reduce the dose should be supervised with follow-up labs to prevent rebound elevations.
Does Tricor cause weight gain or affect blood sugar?
Fenofibrate does not typically cause weight gain and is metabolically neutral for glucose. Some people with diabetes use it safely, but all medications should be individualized.
Can I drink alcohol while taking Tricor?
Moderate alcohol may be permissible, but alcohol raises triglycerides and stresses the liver. Avoid heavy drinking and discuss limits with your clinician, especially if your triglycerides are high or your liver tests are abnormal.
What should I do if I had a night of heavy drinking and take Tricor?
Do not double up. Skip the dose if you’re vomiting or unable to take medications safely; resume the next day when you’re well, and avoid further alcohol. Seek care if you develop severe abdominal pain (possible pancreatitis).
Is Tricor safe during pregnancy?
Fenofibrate is generally avoided in pregnancy unless the potential benefit outweighs the risk, as in cases of severe hypertriglyceridemia with pancreatitis risk. If you become pregnant while on Tricor, contact your clinician promptly to reassess therapy.
Can I take Tricor while breastfeeding?
Breastfeeding is generally not recommended during fenofibrate therapy due to potential effects on the infant. Your clinician can advise on alternatives and timing.
Should I stop Tricor before surgery?
For minor procedures, many clinicians continue Tricor; for major surgery or when you’ll be fasting and at risk of dehydration or kidney stress, your team may hold it temporarily and restart when stable and eating. Always follow the surgeon’s and anesthesiologist’s instructions.
Is Tricor safe if I have liver disease?
Active liver disease or unexplained persistent liver enzyme elevations are contraindications. If you have a history of liver problems, careful monitoring and risk–benefit assessment are essential.
Can people with kidney disease use Tricor?
Dose reduction is required for eGFR 30–59 mL/min/1.73 m², and fenofibrate is generally avoided if eGFR is below 30. Kidney function monitoring is mandatory.
Is Tricor appropriate for older adults?
Yes, but start low and monitor kidney and liver function closely. Older adults may be more sensitive to muscle or kidney side effects, especially with other interacting medicines.
How does Tricor compare to gemfibrozil (Lopid) for high triglycerides?
Both lower triglycerides and raise HDL, but fenofibrate (Tricor) is often preferred because it has a lower risk of dangerous interactions, especially with statins. Efficacy on triglycerides is broadly similar, with regimen choice guided by safety and patient factors.
Is Tricor safer than gemfibrozil when used with a statin?
Yes. Gemfibrozil significantly increases statin levels and muscle toxicity risk; combining gemfibrozil with most statins is discouraged. Fenofibrate can be paired with statins more safely with monitoring.
Tricor vs fenofibric acid (Trilipix): are they the same?
They are closely related; fenofibric acid is the active metabolite of fenofibrate. Some formulations were studied specifically in combination with statins, but in practice both treat high triglycerides similarly—use the product your prescriber selects and monitor appropriately.
Is brand-name Tricor better than generic fenofibrate?
Most patients do equally well on generic fenofibrate of an equivalent formulation. The key is using the correct dose and form; pharmacist verification ensures proper substitution.
How does Tricor differ from older fibrates like clofibrate?
Clofibrate is obsolete due to safety concerns. Fenofibrate has a better safety profile and drug-interaction profile compared to older agents.
Which lowers LDL more: Tricor or gemfibrozil?
Neither is primarily an LDL-lowering drug; effects vary by baseline triglycerides. Fenofibrate may modestly reduce LDL or shift it to larger particles, while gemfibrozil can sometimes raise LDL when triglycerides are very high.
Does Tricor interact less with other drugs than gemfibrozil?
Yes. Gemfibrozil strongly inhibits enzymes and transporters that affect statins and repaglinide, raising adverse-event risks. Fenofibrate has fewer clinically significant interactions but still requires caution with warfarin and cyclosporine.
Which fibrate is better for patients with diabetes?
Both can work, but fenofibrate is often favored for its safety with statins and fewer interactions. Some studies suggest fenofibrate may have microvascular benefits, though it’s not approved specifically for that purpose.
Can Tricor be used if I have moderate kidney impairment compared to gemfibrozil?
Fenofibrate can be used at reduced doses in moderate kidney impairment with monitoring; avoid if severe. Gemfibrozil also needs caution, and in many guidelines fenofibrate is preferred if eGFR is at least 30 and monitoring is feasible.
Do different fenofibrate brands (Antara, Triglide, Lipofen, Tricor) work the same?
They contain fenofibrate but differ in formulation and absorption, which affects dosing and food requirements. Never substitute one for another without prescriber and pharmacist guidance.
Is bezafibrate a better option than Tricor?
Bezafibrate is not approved in the United States and availability varies by country. Data suggest similar triglyceride lowering, but local approvals, evidence, and safety familiarity make fenofibrate the usual choice where available.
How does Tricor compare to pemafibrate?
Pemafibrate is a selective PPAR-alpha modulator studied for triglyceride lowering; large outcome trials have not shown cardiovascular benefit, and approval status varies by region. Fenofibrate remains the established option in many countries.
Does Tricor have a lower risk of muscle problems than gemfibrozil?
Yes. Myopathy and rhabdomyolysis risk is lower with fenofibrate, especially when combined with statins, though any muscle symptoms should be reported promptly.
Is warfarin management different with Tricor versus gemfibrozil?
Both can enhance warfarin’s effect, but gemfibrozil often has more pronounced interactions. With either fibrate, close INR monitoring and dose adjustment of warfarin are necessary when starting or stopping therapy.